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Optimizing folate delivery with Metafolin® (L-5-MTHF)†

An extensive body of evidence indicates that adequate folate intake may provide significant cardiovascular, cellular and neural protection. However, genetic variations affecting activation and metabolism of supplemental folic acid are highly prevalent. In line with our commitment to consistently offer innovative, science-based ingredients, Pure Encapsulations has updated a number of products†, including our multivitamins, to provide Metafolin® (L-5-MTHF). Metafolin® is a naturally occurring, universally metabolized and active form of folate, L-5-MTHF.

As such, it can be directly used in a diverse array of essential methylation reactions to support cardiovascular, neural and emotional health. Additionally, clinical evidence indicates that the bioavailability of Metafolin® is superior to folic acid. In a double-blind, randomized, placebocontrolled intervention study of 144 women of child-bearing age, 5-MTHF supplementation resulted in a greater accumulation of 5-MTHF in red blood cells than equimolar doses of folic acid.

†Some ingredient trademark and patent restrictions may apply to some products, including Folate and PreNatal Nutrients.

Pure Caps with Metafolin		Indications
Nutrient 950®		women 18 to menopause
Nutrient 950® without iron		men and postmenopausal women
Nutrient 950® without copper & iron		men and postmenopausal women
Nutrient 950® without copper, iron & iodine		men and postmenopausal women
Nutrient 950® with NAC		immune defense and detoxification support*
Nutrient 950® with Vitamin K		bone health and arterial calcium metabolism*
Nutrient 280® for Adults		sensitive individuals and children ages 12 and up
UltraNutrient®		cardiovascular and liver health*
Polyphenol Nutrients		cellular, heart, liver, skin, cognitive, macular health*
Multi t/d		two-per-day dosing for optimal compliance; macular support*
Men’s Nutrients		men over 40; prostate health and more*
Women’s Nutrients		women over 40; breast health, hot flashes and more*
Longevity Nutrients		men and women over 60; cognitive support and more*
Athletic Nutrients		training and performance*
PureLean Nutrients		healthy glucose and lipid metabolism*
B-Complex Plus		balanced B vitamin formula
B6 Complex		balanced B vitamin formula with enhanced B6
Homocysteine Factors		cardiovascular health*
B12 Folic		nerve and cognitive function*
Breast Health Complete		general breast health support and comfort*
Lipotropic Detox		healthy hepatic function and detoxification*
Lysine-C Plus		oral immune function*
Vita Essentials		balanced vitamin formula

The Pure Packs incorporating these formulas will also contain Metafolin®